在非临床试验对象中,前面 - 丘脑结构连接与精神分裂,精神病风险表型相关,在非临床试验对象中
Igor Nenadić1,2, Johannes Mosebach1, Simon Schmitt1,2
1Department of Psychiatry and Psychotherapy, Philipps-Universität Marburg, Marburg, Germany.
精神分裂症是一种精神病风险特征,在非临床个体中显示出大脑结构上的差异. 这些发现将精神分裂与前额下皮层和前额叶脑网络联系起来,这表明精神病倾向的生物连续性.
科学领域:
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
背景情况:
- 精神分裂是精神病谱系障碍的风险表型.
- 生物连续性可能是健康和疾病中的精神分裂的基础.
- 精神分裂症谱系障碍网络中的大脑结构关联在精神分裂症中不清楚.
研究的目的:
- 调查与精神分裂特征的非临床受试者的大脑结构关联.
- 探索精神分裂症的生物连续性,跨越健康和疾病.
- 为了检查前端-thalamo-striatal 和默认模式网络改变在精神分裂型.
主要方法:
- 对大量非临床试验对象的多中心队列 (n=673) 的分析.
- 使用思索型人格问卷-简要版本的表型化思索型人格特征.
- 基于扩散张力成像的通道空间统计,基于voxel的形态测量和旋转分析.
主要成果:
- 精神分裂型与主要纤维通道分数异性变异之间有显著的关联.
- 阳性精神分裂与左前丘脑辐射,未切割的囊和环膜负相关.
- 消极的精神分裂与左侧前额膜辐射,环膜体和前额体有正相关;无组织的精神分裂与右侧环膜体和纵向带有负相关.
- VBM 显示灰色质与左小脑负性精神分裂的负相关性.
- 下皮质的转化与负性精神分裂型有正相关.
结论:
- 这些发现支持神经网络对精神分裂型的概念化.
- 精神分裂与前皮下皮层和前系统有关.
- 这些大脑系统作为这种精神病风险表型的结构基质.
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