在pN2乳腺癌患者中的21基因复发评分的利用和结果

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Waqar Haque¹, Vivek Verma², Niva Mangalampalli³

¹Department of Radiation Oncology, Houston Methodist Hospital, Houston, TX, U.S.A.; waqarh786@gmail.com.

Anticancer research

|March 4, 2025

概括

化疗改善了pN2乳腺癌患者的存活率,无论21基因测定复发率 (RS). 在70岁以上的患者中,可以考虑放弃,以支持当前的治疗标准.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
临床研究临床研究

背景情况:

21基因复发率 (RS) 指导早期乳腺癌的化疗.
它在pN2 (4-9阳性淋巴结) 乳腺癌中的实用性尚未得到充分证实.
对PN2疾病的实践模式和结果需要评估.

研究的目的:

为了评估化疗的使用和pN2激素受体阳性,Her2-阴性乳腺癌的结果.
评估21基因RS与化疗治疗的整体存活率 (OS) 之间的关联.
为了为这个特定的患者群体做出治疗决策.

主要方法:

对PN2乳腺癌患者国家癌症数据库 (NCDB) 的分析.
纳入标准:非转移性,激素受体阳性,Her2阴性,已知RS,接受内分泌治疗.
卡普兰-梅尔和考克斯的比例危险建模用于整体生存 (OS) 分析.

主要成果:

分析了1658名患者,67%接受了化疗.
化疗使用与RS风险增加:54% (低),67% (中等),75% (高).
化疗显著改善了所有RS风险组的5年生存率 (p≤0.001).
化疗和RS风险独立地与OS相关 (p<0.05).
70岁以上的患者似乎从化疗中受益较少.

结论:

化疗与所有RS风险组的pN2激素受体阳性,Her2-阴性乳腺癌患者的生存状况改善有关.
目前的化疗标准对这一群体有所支持.
需要考虑在70岁以上的患者中放弃化疗是合理的.

关键词:

乳腺癌是什么? 乳腺癌是什么哺乳动物的印记型型型类型淋巴结的淋巴结是指淋巴结的复发率得分复发率得分

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