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外围CD4+T细胞预测非小细胞肺癌患者肺组织中的T细胞免疫力

Mari Tone^1,2,3, Tomomi Isono⁴, Yoko Yamamoto⁴

¹Department of Cancer Immunotherapy, Osaka International Cancer Institute, Osaka, Japan.

Anticancer research

|March 4, 2025

概括

在非小细胞肺癌 (NSCLC) 患者中,高端CD4+T细胞预测严重的抗PD-1肺炎. 这与肺组织中PD-1+ CD4+ T细胞增加和调控性T细胞减少有关.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
肺部病理学肺部病理学

背景情况:

以前的研究将NSCLC患者的高端CD4+T细胞与抗PD-1疗法的严重免疫相关不良事件 (irAEs) 联系起来.
了解非瘤肺组织中的T细胞免疫力对于预测与抗PD-1相关的肺炎至关重要.

研究的目的:

研究NSCLC患者非瘤肺组织内外围CD4+T细胞子集与T细胞免疫之间的关联.
确定与抗PD-1相关的肺炎的预测生物标志物.

主要方法:

对外围血液和从NSCLC患者手术切除的非瘤肺组织中T细胞概况和功能的分析.
CD4+ T 细胞子集的表征,包括CD45RA+CD25+CD4+ T 细胞和PD-1+ 作用因子调节性T (Treg) 细胞.

主要成果:

具有高百分比的外围CD45RA+CD25+CD4+T细胞的NSCLC患者在非瘤肺组织中表现出高的PD-1+CD4+T细胞.
周围CD4+T细胞的高百分比与肺组织中PD-1+功效Treg细胞的低百分比相关.
降低PD-1+效应Treg细胞与CD4+T细胞的IFNγ和TNFα产生负相关.

结论:

高百分比的外围CD4+T细胞子集增加NSCLC患者的抗PD-1相关肺炎的风险.
肺炎涉及PD-1+CD4+T细胞激活,而肺组织中的Treg细胞没有足够的抑制活性.

关键词:

非小细胞肺癌是非小细胞肺癌.在PD-1中使用PD-1.周围的CD4+ T细胞.监管T细胞的监管性T细胞

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