拒绝手术对黑色素瘤患者整体生存期的影响:综合分析
Reed Popp1, Bansi P Savaliya2, Swathi R Raikot2
1University of Florida College of Medicine, Gainesville, FL, U.S.A.; reedpopp@ufl.edu.
Anticancer research
|March 4, 2025
概括
拒绝手术的黑色素瘤患者通常年龄较大,有更多的健康问题,并面临社会经济劣势. 解决这些障碍可以提高黑色素瘤治疗接受率和生存率.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 公共卫生 公共卫生
背景情况:
- 手术是黑色素瘤的标准治疗方法.
- 患者拒绝手术可能会对生存结果产生负面影响.
- 了解拒绝手术背后的因素对于改善患者护理至关重要.
研究的目的:
- 确定与黑色素瘤患者拒绝手术相关的人口和临床因素.
- 为制定有针对性的干预措施提供信息,以解决手术拒绝的问题.
主要方法:
- 使用国家癌症数据库 (NCDB) 进行回顾性队列研究.
- 对人口,临床和治疗特征的分析.
- 使用Pearson Chi-square和Wilcoxon Rank Sum测试进行统计比较.
主要成果:
- 在1,048,575名黑色素瘤患者中,0.1%的人拒绝接受手术.
- 拒绝者年龄较大 (平均年龄75.8岁),有更多的并发病,并且不成比例地属于种族少数群体或社会经济弱势群体 (p<0.001).
- 拒绝组的整体存活率较低 (66.0%),而非拒绝组 (78.3%).
结论:
- 黑色素瘤手术拒绝与晚年,脆弱和社会经济因素有关.
- 障碍包括种族少数群体地位和较低收入.
- 解决这些障碍的干预措施可能会提高治疗接受率和生存率.
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