对于败血性中性衰竭的新生儿,应该恢复粒细胞输血治疗吗?
1University of Utah, College of Medicine, Department of Pediatrics, Division of Neonatology, 925 Chipeta Dr, Salt Lake City, 84108, UT, USA.
Seminars in fetal & neonatal medicine
|March 4, 2025
概括
颗粒细胞输血可能为新生儿败血症和中子提供新的希望,特别是随着抗菌素耐药性增加. 这篇评论探讨了这种老年疗法对重症新生儿的潜在复活.
科学领域:
- 新生儿医学 新生儿医学
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
背景情况:
- 颗粒细胞输血以前对新生儿败血症和中性质缺血,特别是对格兰氏阴性和真菌感染有效.
- 颗粒细胞殖民地刺激因子的出现和采购挑战导致了颗粒细胞输血的下降.
- 新生儿护理的进步增加了高风险的中性质减退和败血症婴儿的生存率.
研究的目的:
- 审查细粒细胞输血在新生儿的历史使用和演变.
- 根据抗菌素耐药性和新生儿败血症,评估当前对粒细胞输血的需求.
- 为了评估重症新生儿的粒细胞输血复活的潜力.
主要方法:
- 在新生儿医学中对粒细胞输血的文献综述.
- 对输血疗效和安全的历史数据的分析.
- 检查新生儿败血症,中子和抗菌素耐药性的当前趋势.
主要成果:
- 颗粒细胞输血证明了新生儿患有败血症和中性贫血的生存率有所改善,特别是在格兰氏阴性和真菌感染方面.
- 中性贫的新生儿在中性粒细胞数量和功能方面表现出发育缺陷.
- 抗微生物药物耐药性的增加需要对已建立的疗法进行重新评估.
结论:
- 颗粒细胞输血是新生儿败血症和中性衰竭的潜在可行的,尽管较古老的治疗选择.
- 格拉姆阴性感染和抗菌素耐药性的复苏要求重新考虑颗粒细胞输血.
- 对新生儿颗粒细胞输血的现代应用有必要进行进一步的研究.
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