与抗原呈现癌症相关的纤维细胞增强抗瘤免疫力,并预测免疫治疗反应
Junquan Song1,2, Rongyuan Wei1,2, Chenchen Liu1,2
1Department of Gastric Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Nature communications
|March 4, 2025
概括
抗原呈现癌症相关纤维细胞 (apCAF) 在胃癌中增强T细胞免疫力. 这些apCAF可以预测多种癌症类型的免疫治疗反应.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
背景情况:
- 癌症相关纤维细胞 (CAFs) 是瘤进展和免疫调节的关键参与者.
- 在CAF中的功能多样性尚未完全理解,特别是在胃癌 (GC) 中.
研究的目的:
- 在胃癌中识别和表征不同的CAF子集.
- 研究抗原呈现CAFs (apCAFs) 在抗瘤免疫中的作用.
- 探索apCAFs作为免疫治疗反应生物标志物的潜力.
主要方法:
- 基于高MHC II表达在GC瘤中的apCAFs的鉴定.
- 在体内和体外实验中评估apCAF对T细胞和巨细胞的功能.
- 在不同癌症类型的免疫疗法响应者的瘤中对apCAF透的分析.
主要成果:
- 在GC中鉴定出抗原呈现CAF (apCAF),主要在三级淋巴体结构附近.
- apCAFs增强T细胞激活,增殖和细胞毒性能力,增强抗瘤免疫力.
- apCAFs促进促炎性巨细胞两极分化,创造一个积极的反循环,放大免疫反应.
- 较高的apCAF透与各种癌症的免疫治疗反应相关.
结论:
- 这项研究阐明了GC中的CAF异质性,确定apCAFs是关键的免疫调节器.
- apCAFs代表了一个有前途的泛癌生物标志物,用于预测免疫疗法的疗效.
- 向apCAFs可能是增强抗瘤免疫力的治疗策略.
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