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Updated: May 24, 2025

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
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A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

Published on: May 27, 2021

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一个代谢合成的致死性酸酸3-酶驱动的癌症

Guillaume P Andrieu1,2, Mathieu Simonin3,4,5, Aurélie Cabannes-Hamy6

  • 1Laboratory of Onco-Hematology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Universitaire Necker Enfants-Malades, Université Paris Cité, Paris, France. guillaume.andrieu@inserm.fr.

Nature communications
|March 4, 2025
PubMed
概括

针对PI3K驱动的癌症,如T-ALL,包括阻断mTOR和谷氨胺代谢. 这种双重方法利用代谢漏洞来有效治疗癌症.

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