类风湿性关节炎和胰腺炎风险:全国范围的队列研究
Jiho Park1, Yeonghee Eun2, Kyungdo Han3
1Division of Infectious Disease, Department of Internal Medicine, Konkuk University of Medicine, Seoul, Republic of Korea.
Scientific reports
|March 4, 2025
概括
患有类风湿性关节炎 (RA) 的患者患急性胰腺炎的风险略有增加. 虽然慢性胰腺炎的风险在统计学上并不显著,但与对照组相比,RA患者的风险略有增加.
科学领域:
- 类风湿病学 类风湿病学
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病.
- 胰腺炎是胰腺的炎症,可以是急性或慢性.
- 关联RA和胰腺炎风险需要进一步调查.
研究的目的:
- 为了确定患有类风湿性关节炎 (RA) 的患者是否面临患急性和慢性胰腺炎的更高风险.
- 为了比较RA患者的胰腺炎发病率与匹配的对照人群.
主要方法:
- 使用2010-2017年数据进行的回顾性队列研究.
- 鉴定了54,910名RA患者,根据年龄和性别与没有RA的对照进行1:3匹配.
- 使用考克斯回归分析来计算调整的危险比率 (aHR) 和95%置信区间 (CI).
主要成果:
- 在平均5.5年的随访期间,急性胰腺炎发生在0.18%的RA患者和0.14%的对照人群中 (aHR 1.33;95%CI 1.02-1.74).
- 慢性胰腺炎发生在0.11%的RA患者和0.09%的对照人群中 (aHR 1.25;95%CI 0.90-1.74).
- 在RA患者中,急性胰腺炎的风险增加具有统计学意义,而慢性胰腺炎的增加没有显著意义,但显示出边际趋势.
结论:
- 患有类风湿性关节炎的人在统计学上具有明显的急性胰腺炎风险增加.
- 在RA患者中观察到稍微增加慢性胰腺炎风险的趋势,但它没有达到统计学意义.
- 进一步的研究可能会澄清RA和慢性胰腺炎之间的关系.
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