早期营养对大脑发育和非常早产婴儿神经认知结果的影响
Nima Naseh1, Tânia F Vaz2, Hugo Ferreira2
1Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. nima.naseh@uu.se.
Pediatric research
|March 4, 2025
概括
在早产婴儿的早期宏观营养素摄入并没有影响大脑生长或神经发育. 满足当前的营养建议似乎足以支持这些脆弱的婴儿的大脑发育.
科学领域:
- 新生儿科学 新生儿科学
- 神经科学是一个神经科学.
- 营养科学 营养科学
背景情况:
- 早产婴儿的营养不良会影响大脑生长和神经认知结果.
- 了解早期营养对大脑发育的影响对于早产婴儿至关重要.
研究的目的:
- 为了研究非常早产婴儿的宏观营养素摄入量和预产期大脑MRI之间的关联.
- 检查早期营养与2岁神经发育之间的关系.
主要方法:
- 对极度和非常早产婴儿 (2011-2014) 的回顾性队列研究.
- 在前28天评估液体,蛋白质,碳水化合物,脂肪和卡路里摄入量.
- 相关的营养摄入量与大脑MRI在期限和认知得分 (BSID-III) 在2年使用多变量回归.
主要成果:
- 在极度早产的婴儿中,较低的热量摄入量与大脑体积的差异无关.
- 在调整后,宏观营养素摄入量与白质/扩散指标之间的初始相关性并不显著.
- 在对共变量进行调整后,没有发现营养摄入量和认知发育之间的显著关联.
结论:
- 大量营养素摄入的个体变化没有影响符合当前建议的早产婴儿的大脑生长或神经发育.
- 早期产后营养,如果足够,与大脑体积或神经认知结果无关.
- 标准化,充足的宏观营养素摄入量可能足以支持早产婴儿的大脑发育.
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