对接受血液性恶性瘤治疗的女孩的卵巢功能评估
Şule Çalışkan Kamış1, Begül Yağcı2, Ayşe Selcan Koç3
1Division of Pediatric Hematology and Oncology, Department of Pediatric Hematology and Oncology, Adana Faculty of Medicine, Adana City Education and Research Hospital, University of Health Sciences, Adana, Turkey. sulecaliskan87@yahoo.com.
Scientific reports
|March 4, 2025
概括
儿童癌症幸存者经常因为治疗而经历卵巢功能受损. 这项研究使用激素标志物和卵泡计数评估了女性幸存者的卵巢储备,发现了有助于生育计划的相关性.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 儿科瘤学 儿科瘤学
- 在瘤学瘤学.
背景情况:
- 儿童血液性恶性瘤 (例如,急性淋巴细胞白血病,淋巴瘤) 是常见的,化疗和放射治疗对女性幸存者的卵巢功能和生育能力构成风险.
- 癌症治疗对生殖健康的长期影响需要对这些年轻患者的卵巢储备进行仔细评估.
研究的目的:
- 评估儿童血液性恶性瘤的女性幸存者的卵巢功能和储备.
- 在幸存者中评估激素标记物 (AMH,inhibin B,FSH,LH,E2) 和卵巢卵泡计数.
- 为了确定这些标记物和卵巢储备之间的潜在相关性.
主要方法:
- 一项横截面研究包括30名急性白血病,非霍奇金淋巴瘤 (NHL) 和霍奇金淋巴瘤 (HL) 的女性幸存者,他们在2013-2023年期间接受治疗.
- 测量了荷尔蒙标志物 (AMH,inhibin B,FSH,LH,E2) 和卵巢毛囊数量.
- 使用SPSS进行统计分析 (p < 0.05显著程度).
主要成果:
- 在30名幸存者中,86.7%的AMH水平正常,但10%的卵巢储备 (DOR) 减少.
- 在AMH和阻抗B (r=0.508),FSH和阻抗B (r=0.375),阻抗B和毛囊总数 (r=0.444) 之间观察到显著的相关性.
- 在AMH水平和毛囊总数 (r=0.396) 之间发现了适度的相关性.
结论:
- 使用AMH,B抑制素和卵泡计数评估卵巢储备,为儿童癌症幸存者的生育计划提供了关键的见解.
- 早期全面评估卵巢功能对于改善生殖结果和生活质量至关重要.
- 这些发现支持为血性恶性瘤的女性幸存者采取主动的生育保护策略.
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