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Updated: May 24, 2025

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神经元体质突变在多发性硬化病变中增加.

Allan Motyer1,2, Stacey Jackson3, Bicheng Yang4

  • 1Melbourne Integrative Genomics, The University of Melbourne, Melbourne, Victoria, Australia.

Nature neuroscience
|March 4, 2025
PubMed
概括

神经炎症加速了多发性硬化症 (MS) 患者大脑细胞中的遗传突变. 这项研究揭示了MS病变中体质单核酸变体 (sSNV) 的比率更高,这表明炎症是致变的.

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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