较高的相对脂肪质量与美国成年人的胆结石患病率较高有关
Shangfen Xie1, Shanni Ma2, Xiaofeng Chen1
1Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Road, Haishu District, Ningbo City, 315010, Zhejiang Province, China.
BMC gastroenterology
|March 4, 2025
概括
较高的相对脂肪质量 (RFM) 与增加胆结石风险有关. 管理RFM,特别是在生命的早期,可能有助于预防或改善胆结石,在预测中表现优于身体质量指数 (BMI).
科学领域:
- 内分泌学和新陈代谢学
- 公共卫生和流行病学
- 胃肠病学 胃肠病学
背景情况:
- 胆结石是一个重大的公共卫生问题.
- 像体重指数 (BMI) 这样的肥胖指标通常被使用,但可能无法完全捕捉代谢健康.
- 相对脂肪量 (RFM) 提供了一个潜在的更准确的评估脂肪.
研究的目的:
- 调查相对脂肪量 (RFM) 与成年人胆结石患病率之间的关联.
- 为了比较RFM与胆结石形成的身体质量指数 (BMI) 的预测能力.
- 探索潜在的值效应和特定人群的关联.
主要方法:
- 利用了2017-2023年国家健康和营养检查调查 (NHANES) 的数据.
- 采用加权多变量回归,平滑曲线拟合和值效应分析.
- 进行了子组分析,相互作用测试和接收器操作特征 (ROC) 分析.
主要成果:
- 总共有7618名参与者被分析.
- 较高的RFM显著与增加胆结石患病率相关 (OR=1.09,p<0.001).
- 与BMI (AUC=0.674对比0.634) 相比,RFM显示了胆结石的优异预测性能.
结论:
- 升高的RFM是胆结石发展的重要危险因素.
- 在一般人群中,RFM是比BMI更有效的胆结石预测指标.
- 早期的RFM管理可能为胆结石预防和改善提供策略.
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