泛免疫性炎症值:用于诊断儿童尾炎的新生物标志物? 这就是为什么我喜欢它
Nurcan Çoşkun1, Mehmet Metin2, Gül Doğan2
1Department of Pediatric Surgery, Hitit University Erol Olçok Training and Research Hospital, Çorum, Turkey. nurcanerguncoskun19@gmail.com.
全免疫炎症值 (PIV) 指数显示了诊断儿科尾炎的潜力,但需要进一步验证. 当与其他临床和放射学数据一起使用时,PIV可能有助于诊断.
科学领域:
- 儿科手术 儿科手术
- 生物标志物发现发现
- 炎症标记物 炎症标记物
背景情况:
- 急性尾炎是儿童常见的手术紧急情况.
- 准确的诊断对于预防并发症至关重要.
- 需要新的生物标志物来提高诊断准确度.
研究的目的:
- 评估泛免疫炎症值 (PIV) 指数作为儿科尾炎的诊断生物标志物.
- 将PIV的表现与其他系统性炎症指数进行比较.
主要方法:
- 对1514名患有腹部疼痛的儿科患者 (0-18岁) 的回顾性分析.
- 计算PIV,全身炎症指数 (SII),全身炎症反应指数 (SIRI),中性粒细胞与淋巴细胞的比率 (NLR) 和血小板与淋巴细胞的比率 (PLR).
- 进行了接收器操作特征 (ROC) 和多重逻辑回归 (MLR) 分析.
主要成果:
- PIV显示出潜力,最佳切线为919.3,产生72.2%的灵敏度和54.1%的特异性.
- 在MLR中,PIV> 919.3增加了尾炎的可能性2.67倍.
- 其他CRP和PLR等标志物显示预测值较弱.
结论:
- 作为小儿尾炎的新型生物标志物,PIV显示出前景.
- 没有补充的临床和放射学数据,诊断效用是有限的.
- 建议进行更大的前性研究来验证.
更多相关视频
07:38Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
Published on: May 10, 2024
05:31Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
相关概念视频
Appendicitis-I: Introduction
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Appendicitis-II: Diagnostic Studies and Management
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Acute Pancreatitis II: Clinical Manifestations and Management
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
