在患有体征性症状障碍的患者中,小脑的微观结构异常
Wenshuang Tang1, Chao Zhang2,3, Yapeng Qi1
1School of Psychology, Shanghai University of Sport, 399 Changhai Road, Yangpu District, Shanghai, 200438, China.
BMC psychiatry
|March 4, 2025
概括
身体症状障碍 (SSD) 患者表现出大脑小脑微观结构的改变,神经元密度增加和扩散限制. 这些大脑变化与抑郁和焦虑症状相关,表明对慢性压力的适应性反应.
科学领域:
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
- 神经学 神经学
背景情况:
- 身体症状障碍 (SSD) 与健康焦虑和身体症状有关.
- 人们越来越认识到小脑在心理健康,包括SSD中的作用.
- 在SSD中大脑小脑的微观结构变化仍然未被使用扩散核磁共振 (MRI) 探索.
研究的目的:
- 为了研究与健康对照组相比,体征性症状障碍 (SSD) 患者的小脑微结构差异.
- 利用先进的扩散磁共振成像 (dMRI) 技术来分析小脑白质和灰质.
- 为了将观察到的微观结构变化与临床症状严重程度相关联.
主要方法:
- 对30名SSD患者和30名健康对照群进行了横截面研究.
- 基于DSM-5标准的SSD诊断,不包括主要的精神病并发症.
- 扩散MRI (30个方向,b=1000/2000秒/mm2) 和T1加权成像在3T西门子Prisma扫描仪上.
- 使用自由水消除扩散张力成像和神经质定向分散和密度成像 (NODDI) 的分析.
主要成果:
- SSD患者表现出显著的白质变化:自由水消除的分数异构和神经质密度指数增加;自由水消除的平均扩散率和辐射扩散率下降.
- 在26个小脑灰质子区域中观察到显著的微观结构变化.
- 特定的小脑区域 (Vermis X,左叶 VIIb) 显示了微观结构变化和抑郁/焦虑评分之间的相关性.
结论:
- 在SSD患者中,大脑小脑的微观结构变化表明神经元密度更高,扩散限制更强.
- 这些发现可能代表了在SSD中应对慢性压力的适应性神经生物学变化.
- 小脑与体质症状障碍的病理生理学有关.
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