Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

12.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
12.3K
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

38
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
38

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

On the optimization of copy number variations representation in pangenome graphs.

Frontiers in bioinformatics·2026
Same author

A Novel Methodology for a Comprehensive Analysis of Genomic Sequence-to-Graph Alignment Tools.

IEEE transactions on computational biology and bioinformatics·2025
Same author

A Multimodal Transfer Learning Approach for Histopathology and SR-microCT Low-Data Regimes Image Segmentation.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same author

Analysis and Classification of Event-Related Potentials During Image Observation.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2023
Same author

On the Automation of Radiomics-Based Identification and Characterization of NSCLC.

IEEE journal of biomedical and health informatics·2022
Same author

Development of a Deep-Learning Pipeline to Recognize and Characterize Macrophages in Colo-Rectal Liver Metastasis.

Cancers·2021

相关实验视频

Updated: May 24, 2025

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
04:41

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

Published on: January 9, 2020

18.9K

关于GWFA算法的优化:实现支持对齐回溯的实例应用程序.

Mirko Coggi, Antonio Sgarlata, Guido Walter Di Donato

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |March 5, 2025
    PubMed
    概括
    此摘要是机器生成的。

    这项研究引入了对泛基因组学进行改进的图形波面对齐 (GWFA) 算法,使得复杂的基因组图表能够有效地进行长读对齐. 新的实现支持关键的追溯功能,大大加快了分析.

    更多相关视频

    Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
    10:58

    Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

    Published on: July 25, 2013

    17.0K
    Large-area Scanning Probe Nanolithography Facilitated by Automated Alignment and Its Application to Substrate Fabrication for Cell Culture Studies
    09:45

    Large-area Scanning Probe Nanolithography Facilitated by Automated Alignment and Its Application to Substrate Fabrication for Cell Culture Studies

    Published on: June 12, 2018

    9.6K

    相关实验视频

    Last Updated: May 24, 2025

    Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
    04:41

    Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

    Published on: January 9, 2020

    18.9K
    Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
    10:58

    Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

    Published on: July 25, 2013

    17.0K
    Large-area Scanning Probe Nanolithography Facilitated by Automated Alignment and Its Application to Substrate Fabrication for Cell Culture Studies
    09:45

    Large-area Scanning Probe Nanolithography Facilitated by Automated Alignment and Its Application to Substrate Fabrication for Cell Culture Studies

    Published on: June 12, 2018

    9.6K

    科学领域:

    • 基因组学就是基因组学.
    • 生物信息学是一种生物信息学.
    • 计算生物学 计算生物学

    背景情况:

    • 泛基因组图提供了比线性参考更准确的基因变异性表示.
    • 基于图形的基因组分析正在获得引力,最初的工具在序列对齐方面显示出希望.
    • 长读数与基因组图的全球对齐对于识别结构变异和泛基因组学中单元型分相是必不可少的.

    研究的目的:

    • 开发一个开源实现的图形波面对齐 (GWFA) 算法,支持对齐回溯.
    • 通过提供完整的追溯信息来增强泛基因组数据集中的长读数分析.
    • 提供一个更快,更有效的工具,以实现全球对齐的泛基因组学研究.

    主要方法:

    • 开发了一个新的开源实现图形波面对齐 (GWFA) 算法.
    • 将完整的对齐回溯功能集成到GWFA算法中.
    • 确保追溯信息的输出与标准GAF格式兼容.

    主要成果:

    • 与最先进的工具GraphAligner相比,新的GWFA实现实现了20倍的执行时间加快.
    • 该算法展示了竞争性的内存使用情况,同时提供了必要的追溯信息.
    • 成功计算并报告完整的追溯,以便长读对齐到泛基因组图.

    结论:

    • 增强的GWFA算法为基因组学中的长读对齐提供了显著的性能改进.
    • 包括追溯功能对于详细分析结构变异和哈普洛型分阶段至关重要.
    • 这种开源实现为推进泛基因组研究和分析提供了有价值的工具.