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确定患者特异性冠状动脉中稳定状态流动模拟何时总结脉冲式流动力学

Maximilian Huber, Juliet Jiang, Cyrus Tanade

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

|March 5, 2025

概括

稳态计算流体动力学 (CFD) 模型为评估冠状动脉疾病生物标志物提供了对脉动模型的计算效率高的替代方案. 这些更简单的模型准确地捕捉了在腹痛期间的关键血液动力学指标,减少了临床应用的计算负载.

科学领域:

心血管研究研究心血管研究
生物医学工程生物医学工程
计算医学是一种计算医学.

背景情况:

计算模型提供了冠状动脉疾病 (CAD) 生物标志物的非侵入性监测,补充了传统的侵入性方法.
精确的in silico模型的高计算成本,特别是使用脉动流动力学模型的高计算成本,限制了广泛的临床采用.
计算流体动力学 (CFD) 中的脉冲式流量模拟对于捕捉动态血液动力学变化至关重要,但在计算上是密集的.

研究的目的:

评估复杂的脉冲性CFD模型与更简单的稳定状态模型对CAD捕获血液动力学指标的必要性.
确定稳定状态模拟是否可以在临床关键时间点准确地代表患者特定的血液动力学概况.
评估静态和脉动动流模拟在狭窄的冠状动脉之间的计算效率和准确性权衡.

主要方法:

在12名冠状动脉狭窄患者中比较稳定状态和脉动性CFD模拟.
血液动力学指标的分析,包括分数流量储备 (FFR),速度,旋转率和壁切削应力.
在整个心脏周期中对模拟类型之间的度量可比性和分布的评估.

主要成果:

稳定状态和脉动模拟显示出可比的血液动力学指标的大小和分布,特别是在腹痛期间.
输入波形的选择对模拟类型之间结果的可比性影响最小.
稳定状态模拟显示了足够的准确性,像FFR这样的指标,同时显著降低了计算成本.

结论:

稳态CFD模拟足以准确评估关键的血液动力学指标,如CAD中的FFR,特别是在腹痛期间.
脉冲模拟可能是捕捉复杂的缩动态所必需的,但稳定状态模型为更广泛的临床应用提供了计算效率高的替代方案.
选择性应用简化的稳定状态模型可以促进CFD融入临床实践,以管理冠状动脉疾病.

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