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相关概念视频

Fertilization01:38

Fertilization

70.7K
During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
70.7K
Cleavage and Blastulation01:33

Cleavage and Blastulation

44.6K
After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
44.6K
Oogenesis02:07

Oogenesis

63.3K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.3K

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相关实验视频

Updated: May 24, 2025

In Vitro Ovule Cultivation for Live-cell Imaging of Zygote Polarization and Embryo Patterning in Arabidopsis thaliana
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In Vitro Ovule Cultivation for Live-cell Imaging of Zygote Polarization and Embryo Patterning in Arabidopsis thaliana

Published on: September 11, 2017

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卵细胞微观图像受精预测基于使用YOLOv8的第一极体形态学.

Thanakorn Sappakit, Krittapat Onthuam, Tinapat Limsila

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |March 5, 2025
    PubMed
    概括

    这项研究使用人工智能 (AI) 来分析卵细胞中的第一个极体 (PBI),预测在体外受精 (IVF) 中的成功受精和胚胎发育. 人工智能模型在确定PBI和卵细胞发育潜力之间的相关性方面表现出高准确性.

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    Human Egg Maturity Assessment and Its Clinical Application
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    Human Egg Maturity Assessment and Its Clinical Application

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    Whole Ovary Immunofluorescence, Clearing, and Multiphoton Microscopy for Quantitative 3D Analysis of the Developing Ovarian Reserve in Mouse

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    相关实验视频

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    Human Egg Maturity Assessment and Its Clinical Application
    08:51

    Human Egg Maturity Assessment and Its Clinical Application

    Published on: August 19, 2019

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    Whole Ovary Immunofluorescence, Clearing, and Multiphoton Microscopy for Quantitative 3D Analysis of the Developing Ovarian Reserve in Mouse
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    科学领域:

    • 生殖生物学 生殖生物学
    • 医疗成像医学成像
    • 人工智能的人工智能

    背景情况:

    • 在体外受精 (IVF) 中,卵细胞的发育对于胚胎的生存能力和生育能力至关重要.
    • 第一个极体 (PBI) 是影响卵细胞发育能力的潜在因素,尽管其作用仍在争论中.
    • 精确预测受精成功和随后的胚胎发育在辅助生殖技术中至关重要.

    研究的目的:

    • 研究第一极体 (PBI) 与卵细胞发育能力之间的相关性.
    • 开发和验证基于人工智能的管道,用于预测成功的卵细胞受精和发展到两个前核 (2PN) 阶段.
    • 评估卷积神经网络 (CNN) 在分析微观卵子细胞图像中的实用性,用于预测目的.

    主要方法:

    • 开发了一个利用You Only Look Once (YOLO) 卷积神经网络 (CNN) 的管道,包括细分和分类模型.
    • 采集了二元期II (MII) 卵子细胞的光显微镜图像,并使用CNN对PBI进行细分和切割.
    • 然后将剪切的PBI图像输入到CNN分类中,以预测在细胞内质精子注射 (ICSI) 后成功开发2PN的可能性.

    主要成果:

    • 在1006张图像的数据集上,YOLOv8l-cls模型实现了高性能,精度为96.98%,灵敏度为95.69%,特异性为98.28%.
    • 人工智能模型成功地预测了仅基于PBI图像分析的2PN开发潜力,而不需要额外的功能.
    • 结果表明PBI特征与卵细胞发育潜力之间存在显著的相关性.

    结论:

    • 这项研究证明了AI,特别是YOLO CNNs在分析PBI形态来预测卵细胞发育能力方面的有效性.
    • 开发的AI管道提供了一种非侵入性方法来评估卵细胞质量并预测IVF受精成功.
    • 这些发现有助于更好地了解PBI在卵细胞发育中的作用,并对改善试管婴儿结果产生潜在影响.