转交替电流刺激诱导相位训练和皮质脊髓刺激能力的塑性促进
Asher Geffen1, Nicholas Bland1, Martin V Sale1
1School of Health and Rehabilitation Sciences, The University of Queensland, St Lucia, Queensland, Australia.
The European journal of neuroscience
|March 5, 2025
概括
跨交替电流刺激 (tACS) 显示了神经携带和神经可塑性的证据. 这项研究使用tACS与TMS和EEG一起研究这些对感觉运动节律和皮质脊髓刺激性的影响.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 神经调节是一种神经调节.
背景情况:
- 理论上,跨交替电流刺激 (tACS) 通过引入和神经可塑性来调节神经活动.
- 了解这些机制对于优化tACS协议至关重要.
研究的目的:
- 为了研究tACS在传感动力μ-rhythm上的机制.
- 评估在线引诱和离线神经塑性后果对皮质脊髓刺激性 (CSE) 和μEEG功率的后果.
主要方法:
- 在13名参与者中利用了跨磁刺激 (TMS) 和脑电图 (EEG).
- 应用了个性化μ频 tACS (IMF) 在每次会议90次试验,共3次.
- 在刺激期间和之后的不同时间点测量了运动唤起潜力 (MEP) 和静止EEG活动.
主要成果:
- 初步证据表明,皮质脊髓刺激性 (CSE) 诱导在tACS.之后立即持续存在.
- 在μ-tACS.之后复制了之前观察到的塑料CSE促进.
- 确认了μEEG功率的调制.
结论:
- 在调节神经活动方面,tACS显示出了引进和神经可塑性机制.
- 这些发现支持tACS在传感运动网络上的双重作用.
- 为完善tACS在神经科学中的应用提供了基础.
相关概念视频
Long-term Potentiation
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Long-term Potentiation
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Hebbian LTP
LTP can occur when presynaptic neurons...
Motor Unit Stimulation
When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
Muscle Stimulation Frequency
The contraction strength of muscles is regulated by motor neurons, which modulate the frequency of action potentials dispatched to the motor units based on the body's requirements. This process of varying the muscle stimulation frequency allows muscles to contract with a force that is precisely tailored to the needs of the moment, whether lifting a feather or a heavy box.
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...


