与痴呆症风险相关的非类固醇抗炎药物的长期暴露
Ilse Vom Hofe1, Bruno H Stricker1, M Kamran Ikram1,2
1Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Journal of the American Geriatrics Society
|March 5, 2025
概括
长期使用非类固醇抗炎药物 (NSAIDs) 与痴呆症风险降低有关. 然而,累积剂量和短期使用并没有显示出类似的保护作用,这表明持续时间对潜在的痴呆症预防至关重要.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 流行病学 流行病学
背景情况:
- 非类固醇抗炎药物 (NSAIDs) 具有抗炎和潜在的粉样蛋白降低特性,可以降低痴呆风险.
- 关于NSAID使用和痴呆风险的现有研究已经产生了不一致的发现,剂量-反应和持续时间的关系不清楚.
研究的目的:
- 调查NSAID使用的累积持续时间和剂量与发展痴呆症的风险之间的关联.
- 探索具有已知的粉样蛋白降低特性的NSAIDs是否与没有这种特性的NSAIDs相比,对痴呆风险的影响不同.
主要方法:
- 分析了前性鹿特丹研究中11745名没有痴呆症的参与者的数据.
- 根据药房记录,根据累积持续时间 (不使用,短期,中期,长期) 分类的NSAID使用.
- 考克斯回归模型,调整了混因素,评估了痴呆风险与随时间变化的NSAID暴露的相关性,按粉样β特性分层.
主要成果:
- 长期使用NSAID (24个月以上) 与痴呆症风险降低有关 (HR:0.88 [0.84-0.91]).
- 短期 (<1个月) 和中期 (1-24个月) 的NSAID使用显示出轻微增加痴呆风险 (HR:1.04 [1.02-1.07]和1.04 [1.02-1.06].
- 累积的NSAID剂量与痴呆症风险的降低无关;对于没有已知的粉样β影响的NSAID,相关性更强.
结论:
- 长时间使用NSAID,而不是累积剂量,似乎与痴呆的风险较低有关.
- 研究结果表明,暴露于抗炎药物的持续时间可能比使用强度对预防痴呆更为关键.
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