在肝脏中产生阿尔多斯减少酶,果糖和脂肪
Peter Delannoy1, Dean R Tolan2, Miguel A Lanaspa3
1Orgins of Human Metabolic Disease, Phoneix, AZ,85016, U.S.A.
The Biochemical journal
|March 5, 2025
概括
通过阿尔多减少酶 (AR) 调节的多途径内源性果糖生产可能会显著促进非酒精性脂肪肝疾病 (NAFLD). 高血糖激活了这种途径,影响了果糖代谢和慢性代谢疾病.
科学领域:
- 生物化学 生物化学
- 代谢疾病 代谢疾病
- 肝病学 肝病学是一种肝病学.
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 越来越多地与果糖消费有关.
- 果糖可以通过多路径从葡萄糖内源地产生.
- 阿尔多减少酶 (AR) 控制了多途径的接入和果糖的产生.
研究的目的:
- 审查阿尔多减少酶 (AR) 的生物化学.
- 阐明聚醇途径在果糖代谢中的作用.
- 为内生果糖生产在NAFLD中的重要性提供一个新的视角.
主要方法:
- 关于阿尔多减少酶 (AR) 生物化学的文献综述.
- 对聚醇通路的调节和酶的分析.
- 探索葡萄糖对果糖-尿酸通路的激活.
主要成果:
- 通过多路径内源性果糖的产生可能比以前认为的更为重要.
- 阿尔多减少酶 (AR) 在将葡萄糖转移到多途径中发挥着关键作用.
- 高血糖激活了与NAFLD相关的果糖-尿酸通路.
结论:
- 由AR调节的多路径是内源果糖生产的关键决定因素.
- 通过高葡萄糖水平激活这种途径有助于NAFLD.
- 了解AR和聚醇途径为慢性代谢疾病提供了洞察力.
相关概念视频
Glycolysis: Preparatory Phase
13.2K
In cellular metabolism (the complete breakdown of glucose to extract energy), glycolysis is the first step. Glycolysis takes place in the cytoplasm of both prokaryotic and eukaryotic cells. Glucose enters heterotrophic cells in two ways. One method is through secondary active transport, where the transport takes place against the glucose concentration gradient. The other mechanism uses a group of integral proteins called GLUT proteins, also known as glucose transporter proteins. These...
13.2K
Phase I Reactions: Reductive Reactions
171
Phase I biotransformation reductive reactions are chemical processes that modify drugs by introducing or revealing polar functional groups via reduction. Enzymes called reductases catalyze these reactions, playing a pivotal role in drug metabolism by transforming lipophilic drugs into more polar, water-soluble metabolites for easy excretion. An essential type of reductive reaction is the carbonyl group reduction, where aldehydes and ketones are reduced to alcohols. An example is the...
171
Energy-requiring Steps of Glycolysis
162.8K
Glucose is the source of nearly all energy used by organisms. The first step of converting glucose into usable energy is called glycolysis. Glycolysis occurs in the cytosol of the cell over two phases: an energy-requiring phase and an energy-releasing phase. Over the first three steps, glucose is converted into different forms and attached to two phosphate groups donated by two ATP molecules, resulting in an unstable sugar. In the next two stages, the unstable sugar splits into two sugar...
162.8K
Overview of Carbohydrate Metabolism
666
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
666
Alcohols from Carbonyl Compounds: Reduction
10.2K
Reduction is a simple strategy to convert a carbonyl group to a hydroxyl group. The three major pathways to reduce carbonyls to alcohols are catalytic hydrogenation, hydride reduction, and borane reduction.
Catalytic hydrogenation is similar to the reduction of an alkene or alkyne by adding H2 across the pi bond in the presence of transition metal catalysts like Raney Ni, Pd–C, Pt, or Ru. Aldehydes and ketones can be reduced by this method, often under mild to moderate heat (25–100°C) and...
Catalytic hydrogenation is similar to the reduction of an alkene or alkyne by adding H2 across the pi bond in the presence of transition metal catalysts like Raney Ni, Pd–C, Pt, or Ru. Aldehydes and ketones can be reduced by this method, often under mild to moderate heat (25–100°C) and...
10.2K
Liver Physiology
405
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
405


