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相关概念视频

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications
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循环非编码RNA作为固体瘤液体活检的工具.

Beyza Karaca Dogan1, Seda Salman Yilmaz1,2, Gizem Nur Izgi1

  • 1Department of Medical Genetics, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa, Istanbul, Turkiye.

Epigenomics
|March 5, 2025
PubMed
概括

液体活检中循环的非编码RNA显示出早期癌症诊断和监测固体瘤治疗反应的前景. 研究强调了微RNA,长非编码RNA和其他小RNA的诊断和治疗潜力.

关键词:
没有编码的RNAs.生物标志物 生物标志物循环的循环循环的循环表观遗传规则 表观遗传规则在ncRNA中,我们可以这是一个微型RNA.固体瘤是一种固体瘤.

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科学领域:

  • 在瘤学瘤学.
  • 分子生物学分子生物学
  • 生物化学 生物化学

背景情况:

  • 固体瘤是全球主要的健康负担,推动了对非侵入性诊断和监测工具的研究.
  • 液体活检为检测癌症特异性分子提供了一个有希望的途径,因为它们的可访问性和随着疾病进展或治疗的动态变化.
  • 循环非编码RNAs (ncRNAs) 正因其稳定性和在体液中作为生物标记物的潜力而受到越来越多的关注.

研究的目的:

  • 审查在固体瘤中最受研究的循环非编码RNA.
  • 讨论这些ncRNAs对于早期诊断,预后和治疗点的重要性.
  • 根据从2008年到2024年6月的文献,提供该领域的进展概述.

主要方法:

  • 在PubMed数据库中进行文献搜索.
  • 对聚焦于固体瘤中循环非编码RNA的出版物的分析.
  • 审查研究这些分子的诊断,预后和治疗影响的研究.

主要成果:

  • 微RNAs (miRNAs) 已被广泛研究为循环生物标志物.
  • 观察到对其他ncRNAs越来越感兴趣,包括长非编码RNAs (lncRNAs),piwi相互作用RNAs (piRNAs) 和循环RNAs (circRNAs).
  • 这些循环的ncRNAs显示出非侵入性早期诊断的潜力,预测患者的结果,并指导固体瘤的治疗策略.

结论:

  • 循环非编码RNA代表了固体瘤生物标记物的有价值类别.
  • 它们的实用性涵盖了早期检测,预后评估和开发新型治疗策略.
  • 在液体活检中对不同ncRNA物种进行进一步的研究是有必要的,以充分利用它们的临床潜力.