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硫化修复丸受热应激引起的丸损伤在老鼠中
Xinyu Guo1,2, Yupeng Yin3, Susu Guo1
1Center of Reproductive Medicine, The General Hospital of Southern Theater Command, Guangzhou, China.
FEBS open bio
|March 5, 2025
概括
硫化 (H2S) 保护男性的生育能力免受热应激. 这项研究表明,H2S治疗可以通过减少老鼠的炎症和氧化应激来逆转热引起的丸损伤.
科学领域:
- 生殖生物学 生殖生物学
- 生物化学 生物化学
- 毒理学 毒理学 毒理学
背景情况:
- 热应激对男性生殖健康和生育能力产生负面影响.
- 硫化 (H2S) 是一种气体递质,具有抗氧化和抗炎性质.
- 研究H2S对热引起的丸损伤的保护作用至关重要.
研究的目的:
- 为了确定H2S的管理是否可以减轻由热应激引起的丸损伤.
- 阐明H2S发挥保护作用的机制.
主要方法:
- 建立了一种热应激的老鼠模型.
- 使用H2S供体 (NaHS) 进行治疗.
- 采用了组织病理学,高通量测序,生物信息学和分子分析.
主要成果:
- 热应激会影响丸指数,精子质量和荷尔蒙水平,同时增加炎症.
- H2S治疗恢复了丸功能,改善了精子质量,并使激素水平正常化.
- H2S降低了炎症标志物 (TNF-α,IL-1β,IL-6),氧化应激 (MDA) 和增强了抗氧化能力 (catalase,GSH/GSSG比率).
结论:
- 在老鼠中,H2S捐赠者NaHS有效地减轻热应激诱导的丸损伤.
- H2S通过抑制炎症反应和氧化应激来保护丸功能.
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