后突触突刺测定视觉皮层篮细胞中的反Hebbian LTD.
Christina Y C Chou1,2, Wouter J Droogers1, Txomin Lalanne1,3
1Centre for Research in Neuroscience, BRaIN Program, Department of Neurology and Neurosurgery, Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, QC, Canada.
Frontiers in synaptic neuroscience
|March 5, 2025
概括
在视觉皮层发育中的金字塔细胞到篮细胞 (PC→BC) 突触的长期可塑性对后突触增长敏感. 这种尖端影响树突性动力学,导致当输入先于尖端时,导致反赫比长期抑郁 (LTD).
科学领域:
- 神经科学是一个神经科学.
- 突触性可塑性 突触性可塑性
- 皮层微电路 皮层微电路
背景情况:
- 在金字塔细胞到篮细胞 (PC→BC) 突触的长期可塑性对于皮质微电路功能至关重要.
- 虽然PC→PC突触的长期增强 (LTP) 与树突性 (Ca2+) 动力学和巧合的尖端相关,但PC→BC突触在初级视觉皮层 (V1) 的机制不太了解.
研究的目的:
- 调查PC→BC突触可塑性在V1发育过程中对突触后尖刺的敏感性.
- 阐明树突Ca2+动态在调解这种可塑性中的作用.
主要方法:
- 两光子 (2P) Ca2+成像用于观察V1层-5 (L5) 篮细胞 (BCs) 中的动作电位 (AP) 反向传播.
- 将刺激输入与后突触AP配对,以评估树状Ca2+超线性.
- 细胞外刺激和高通量2P光遗传映射来诱导和测量突触可塑性.
主要成果:
- APs在V1 L5 BC树突中的PC→BC突触接触点上积极反传播.
- 对于前前后突触输入配对,观察到状Ca2+超线性,但对前前前前突触输入配对没有观察到.
- 前前后交互的配对诱导了反赫比长期抑郁症 (LTD),而后前前交互的配对没有.
结论:
- V1 BC 树突性 Ca2+ 非线性对体质刺敏感.
- 在PC→BC连接处的突触可塑性取决于突触前输入和突触后尖端的时间顺序,有利于使用反赫比规则的LTD.
相关概念视频
Long-term Depression
30.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
30.5K
Long-term Potentiation
2.7K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
Hebbian LTP
LTP can occur when...
2.7K
Integration of Synaptic Events
1.4K
Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability...
1.4K
Postsynaptic Potential (PSP)
2.3K
Postsynaptic potential (PSP) refers to a change in the electrical potential of a neuron when neurotransmitters released by presynaptic neurons bind to postsynaptic receptors. This potential can either be excitatory, leading to depolarization and ultimately action potential generation, or inhibitory, leading to hyperpolarization and suppression of the postsynaptic neuron.
There are two types of receptors: ionotropic and metabotropic.
The ionotropic receptor is the membrane protein that has an...
There are two types of receptors: ionotropic and metabotropic.
The ionotropic receptor is the membrane protein that has an...
2.3K


