调节 nociception 网络:低强度聚焦超声波对 thalamocortical 连接性的影响
Arabinda Mishra1,2, Pai-Feng Yang1,2, Thomas J Manuel3
1Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA.
Brain communications
|March 5, 2025
概括
低强度的聚焦超声波通过准乳头来非侵入性调节疼痛网络. 这种方法精确地改变了甲状腺皮层的功能连接,提供了一个有前途的非侵入性疼痛管理策略.
科学领域:
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
- 神经调节是一种神经调节.
背景情况:
- 疼痛感知涉及复杂的甲状腺皮层网络,甲状腺作为一个关键的枢纽.
- 理解和调节这些网络对于开发有效的疼痛疗法至关重要.
研究的目的:
- 为了研究MR指导的聚焦超声波 (FUS) 对thalamocortical nociceptive网络组织的影响.
- 探索FUS作为一种用于疼痛管理的非侵入性神经调节工具的潜力.
主要方法:
- 使用MR导向的FUS与实时反和fMRI以准和抑制在体腹后侧核 (VPL) 中的活性,以应对感知热刺激.
- 绘制全脑血液氧化水平依赖 (BOLD) 反应的地图,并使用心理物理相互作用方法分析有效功能连接 (EFC).
- 采用等级聚类来识别和分析thalamocortical子网络.
主要成果:
- 在 nociceptive 处理过程中确定了 19 个皮质区域,具有强烈的 EFC 到体 VPL.
- 在thalamic VPL中由FUS诱导的抑制改变了大多数连接的皮层区域的感知反应.
- FUS调节了皮层连接强度,并重组了已识别的子网络.
结论:
- 体VPL与广泛的皮层区域有着广泛的因果关系,这些区域参与了感觉处理.
- 结合fMRI的MR引导FUS允许精确剖析和调制大脑网络.
- 这种非侵入性方法通过准甲状腺皮层网络,显示出治疗疼痛的巨大潜力.
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