父亲年龄和新生儿结果:基于人口的队列研究
Wenxue Xiong1, Xijia Tang1, Lu Han2
1Department of Medical Statistics, School of Public Health, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Human reproduction open
|March 5, 2025
概括
父亲年龄与早产和剖腹产风险的增加有关. 这一发现凸显了在怀孕前咨询怀孕风险时考虑父亲年龄的重要性.
科学领域:
- 生殖健康 生殖健康
- 围产儿医学 围产儿医学
- 流行病学 流行病学
背景情况:
- 先进的母亲年龄是新生儿不良后果的已知风险因素.
- 父亲年龄与新生儿结局之间的关联不太清楚,但由于精子中的潜在遗传和表观遗传变化,在生物学上是合理的.
- 本研究探讨了父亲年龄与各种新生儿结局之间的联系.
研究的目的:
- 确定父亲的年龄是否与新生儿不良后果有关.
- 量化特定结果的风险,如早产和剖腹产,与父亲的年龄相关.
- 为了比较父亲年龄与母亲年龄对新生儿结果的影响.
主要方法:
- 一项基于中国广东省783,988名母亲-新生儿-父亲三人组的基于人口的队列研究 (2014-2019).
- 修改Poisson和后勤回归模型被用于分析关联和相对重要性.
- 限制性立方线模拟了非线性剂量反应关系;评估了父母年龄之间的附加相互作用.
主要成果:
- 与25-34岁的父亲相比,35-44岁的父亲与剖腹产 (RR: 1.07) 和早产 (PTB) (RR: 1.15) 的风险更高.
- 观察到PTB风险与父亲年龄的增加之间存在J形,剂量依赖的关联 (非线性P<0.001).
- 与母亲的年龄相比,父亲的年龄对PTB和剖腹产的预测重要性相似或更大;与SGA或PID的关联并不重要.
结论:
- 父亲的年龄独立地与剖腹产和早产的风险增加有关.
- 研究结果表明,在怀孕前咨询中应考虑父亲的年龄,以了解与年龄相关的怀孕风险.
- 需要进一步研究增加父亲年龄对公共卫生的影响.
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