酶疗法与视频辅助胸腔镜手术治疗多叶膜感染:系统性审查和元分析
Weija R de Jonge1, Bo Smits1, Johannes C F Ket2
1Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Cardiothoracic Surgery, Amsterdam, The Netherlands.
ERJ open research
|March 5, 2025
概括
与内酶治疗 (IET) 相比,视频辅助胸腔镜手术 (VATS) 可能会减少对肺部肺部肺部感染的住院时间. 然而,随机试验的结果是不确定的,强调需要进一步对这些肺部感染进行高质量的研究.
科学领域:
- 胸部外科手术 胸部外科手术
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 副肺性膜感染很常见,但最佳治疗仍在争论中.
- 目前的治疗方案包括肌内酶疗法 (IET) 和视频辅助胸腔镜手术 (VATS).
研究的目的:
- 系统地审查和比较立即VATS与IET对于肺周肺部感染的疗效.
- 评估两种治疗方式之间的住院时间,死亡率和发病率的差异.
主要方法:
- 对成年患者的IET和VATS进行比较的研究进行系统审查和元分析.
- 在 MEDLINE,Embase 和 Web of Science 数据库中搜索到 2023 年 11 月.
- 使用ROBINS-I和ROB 2评估研究质量,并进行逆方差随机效应元分析.
主要成果:
- 包括8项研究,包括1023名患者;大多数是非随机的,具有高偏差风险.
- 对非随机研究的分析显示,使用VATS的住院时间较短 (MD4.2天).
- 没有观察到死亡率或发病率的显著差异;随机可行性研究给出了不确定的结果.
结论:
- 与IET相比,VATS可能会根据非随机数据提供较短的住院时间,用于与IET相比的肺部肺部肺部感染.
- 在包含的非随机研究中存在偏差的高风险限制了最终的结论.
- 需要进一步进行高质量的随机对照试验,以确定最佳的治疗策略.
相关概念视频
Enzymes
80.4K
Inside living organisms, enzymes act as catalysts for many biochemical reactions involved in cellular metabolism. The role of enzymes is to reduce the activation energies of biochemical reactions by forming complexes with its substrates. The lowering of activation energies favor an increase in the rates of biochemical reactions.
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...
80.4K
Introduction to Enzymes
17.0K
The use of enzymes by humans dates to 7000 BCE. Humans first used enzymes to ferment sugars and produce alcohol without knowing that this was an enzyme-catalyzed reaction. Wilhelm Kuhne coined the term 'enzyme' in 1877 from the Greek words ‘en’ meaning ‘in’ or ‘within’ and ‘zyme’ meaning ‘yeast.’
Most enzymes are proteins that speed up biochemical reactions without being consumed. Enzymes contain one or more active sites that...
Most enzymes are proteins that speed up biochemical reactions without being consumed. Enzymes contain one or more active sites that...
17.0K
Ribozymes
11.1K
The term ribozyme is used for RNA that can act as an enzyme. Ribozymes are mainly found in selected viruses, bacteria, plant organelles, and lower eukaryotes. Ribozymes were first discovered in 1982 when Tom Cech’s laboratory observed Group I introns acting as enzymes. This was shortly followed by the discovery of another ribozyme, Ribonulcease P, by Sid Altman’s laboratory. Both Cech and Altman received the Nobel Prize in chemistry in 1989 for their work on ribozymes.
Ribozymes can...
Ribozymes can...
11.1K
Enzyme Inhibition
77.7K
Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.
77.7K
Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
Introduction to Mechanisms of Enzyme Catalysis
7.9K
For many years, scientists thought that enzyme-substrate binding took place in a simple "lock-and-key" fashion. This model stated that the enzyme and substrate fit together perfectly in one instantaneous step. However, current research supports a more refined view scientists call induced fit. The induced-fit model expands upon the lock-and-key model by describing a more dynamic interaction between enzyme and substrate. As the enzyme and substrate come together, their interaction causes...
7.9K


