头部和部结构的组织特定重建建模及其在模拟气道阻塞中的应用
Huahui Xiong1,2, Hui Tong1,2, Yuhang Tian1,2
1School of Biomedical Engineering, Capital Medical University, Beijing, China.
Heliyon
|March 5, 2025
概括
这项研究引入了一种使用多方向成像的新型3D头部和部重建方法. 该技术准确地模拟了气道崩,有助于诊断像阻塞性睡眠呼吸暂停这样的疾病.
科学领域:
- 生物医学工程 生物医学工程
- 医疗成像医学成像
- 计算解剖学的计算解剖学
背景情况:
- 头部和部组织的3D重建在临床上很重要,但由于解剖学复杂性,缺乏完整的方案.
- 现有的方法难以有效地捕获各种组织轮信息.
研究的目的:
- 建立一个组织特定的多方向横截面图像序列构造方法,用于头部和部3D重建.
- 为了捕获各种组织轮信息并提高解剖学建模的准确性.
主要方法:
- 从3DMRI数据构建非传统的图像序列,根据特定组织特征量身定制.
- 利用有效的注册策略,从多个序列中整合细分的组织边界.
- 用于3D表面建模和流体结构相互作用模拟的非统一理性B-Splines (NURBS).
主要成果:
- 成功重建了完整的3D头部和部结构,包括上呼吸道组织.
- 开发非线性注册方法,准确匹配不同图像序列的组织边界.
- 在患者和正常人中模拟上呼吸道崩,提供详细的变形数据和预测临界关闭压力.
结论:
- 建立了一个全面的3D重建方案,从多方向图像序列构建到表面生成.
- 开发的模型准确地代表了解剖结构,并且适用于上呼吸道崩的复杂数值模拟.
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