研究腹腔内德克萨米他,德克斯梅托米丁及其组合在腹腔镜胆囊切除术后对PONV的影响:一项随机的三盲试验
Hany Bauiomy1, Neveen A Kohaf2, Mohammed Saad3
1Department of Anesthesia & Intensive Care, Faculty of Medicine, Benha University, Benha, Egypt.
Anesthesiology research and practice
|March 5, 2025
概括
在腹腔镜胆囊切除术后,内甲和德克斯梅德托米丁有效降低了术后的恶心和吐 (PONV). 组合疗法在预防PONV患者中表现出最大的疗效.
科学领域:
- 麻醉学和外科手术期间的医学.
- 外科胃肠道外科手术
- 药理学 药理学是指药理学的学科.
背景情况:
- 手术后恶心和吐 (PONV) 是腹腔镜胆囊切除术后的常见和重大并发症.
- 为了减轻PONV,使用各种药理学药物,成功程度各不相同.
研究的目的:
- 评估内皮层内给药的德克萨米他,德克斯梅托米丁及其组合的抗发疗效.
- 在全身麻醉下进行腹腔镜胆囊切除术的患者中,比较这些药物的疗效与安慰剂.
主要方法:
- 一项前性,随机的,三盲研究,涉及240名患者 (20-50岁,ASA I-II) 进行腹腔镜胆囊切除术.
- 患者被分配到四个组:对照组 (正常盐水),德克萨梅他 (8毫克),德克斯梅德托米丁 (1微克/公斤) 或组合.
- 药物被输入腹腔内,PONV的发病率和抗药的需要在手术后24小时内被记录下来.
主要成果:
- 与对照组 (43.33%) 相比,德克萨米他 (16.67%),德克斯米德托米丁 (18.33%) 和组合剂 (10%) 组的恶心发病率明显较低.
- 在治疗组 (18.33%,16.67%,8.33%) 和对照组 (41.67%) 中,吐率也显著降低.
- 组合组表现出最低的恶心,吐和抗药需求率 (p < 0.05).
结论:
- 德克萨米他和德克斯梅德托米丁单独或组合的内注射显著降低了PONV的发病率.
- 在这个患者队列中,组合疗法在预防PONV方面表现出比单疗法或安慰剂更高的疗效.
- 这项研究支持腹腔内路线作为使用这些药物预防PONV的有效方法.
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