肝细胞生长因子和B型天然尿素作为HFpEF患者死亡率的独立预测因子
Hou-Liang Chen1,2, Xue-Tao Zhu1, Wang Zhang3
1Department of Cardiology, The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China.
Frontiers in cardiovascular medicine
|March 5, 2025
概括
肝细胞生长因子 (HGF) 和B型天然尿素前体 (BNP) 是心力衰竭死亡率的关键预测因子,其中保留喷射分数 (HFpEF). 较低的HGF和BNP水平表明HFpEF患者的生存概率更高.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 心脏衰竭研究研究
背景情况:
- 保存喷射分数 (HFpEF) 的心力衰竭是一种普遍且复杂的疾病,与显著的死亡率和发病率有关.
- 关于生物标志物对HFpEF患者结果的预测价值的研究有限.
研究的目的:
- 研究血肝细胞生长因子 (HGF) 水平与被诊断患有HFpEF的患者全因死亡率之间的关联.
- 确定HFpEF中死亡率的独立风险因素.
主要方法:
- 一项回顾性队列研究包括412名HFpEF患者,随访时间为24个月.
- 使用多变量逻辑回归和卡普兰-梅尔分析来评估死亡风险因素.
- 接收机运行特征 (ROC) 曲线分析评估了关键指标的预测性表现.
主要成果:
- 肝细胞生长因子 (HGF),B型尿素前体 (BNP),总蛋白质 (TP),估计的淋巴细胞过率 (eGFR) 和四甲状腺素 (T4) 被确定为死亡的独立风险因素 (P <0.05).
- 在ROC分析中,HFpEF死亡率中,HGF (AUC=0.645) 和BNP (AUC=0.703) 的预测值显著.
- 卡普兰-梅尔分析显示,HGF和BNP度较低的患者的生存概率显著更高 (P < 0.0001).
结论:
- HGF和BNP是HFpEF患者24个月全因死亡率的重要独立风险因素.
- 升高的HGF和BNP水平与死亡风险增加有关.
- 较低的HGF和BNP度与HFpEF中改善的生存结果相关.
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