学校HPV疫苗接种计划中的性别中立与性别特定策略:系统性审查和元分析
Nutthaporn Chandeying1, Puttichart Khantee2, Sirada Puetpaiboon2
1Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand.
Frontiers in public health
|March 5, 2025
概括
性别中立 (GN) 策略改善了HPV疫苗接种知识和意图,而不是性别特定 (GS) 方法. 虽然GN显示了更高的吸收率,但需要进一步的研究来证实其对GS策略的统计意义.
科学领域:
- 公共卫生 公共卫生
- 疫苗学 疫苗学 疫苗学
- 卫生教育卫生教育教育
背景情况:
- 人类乳头瘤病毒 (HPV) 疫苗接种对于预防HPV相关癌症至关重要.
- 教育环境是实施疫苗接种促进战略的关键环境.
- 评估性别中立与性别特定方法的有效性对于优化HPV疫苗接种活动至关重要.
研究的目的:
- 系统地审查和元分析性别中立 (GN) 与性别特定 (GS) 策略在学生对HPV疫苗接种知识,意图和接种方面的有效性.
- 为了比较GN和GS战略在教育环境中的影响.
主要方法:
- 在主要数据库 (PubMed,Scopus,Web of Science,Cochrane Library) 中进行了全面的文献搜索.
- 包括17个随机对照试验 (RCT) 与22,435名参与者.
- 随机效应模型用于计算知识和意图的标准化平均差异 (SMD),以及接种疫苗的风险差异.
主要成果:
- 与GS策略相比,GN策略在知识 (SMD = 0.95) 和意图 (SMD = 0.59) 中的改进显著更高 (SMD = 0.68对知识,SMD = 0.14对意图).
- 与GS策略 (2.5%) 相比,GN策略导致HPV疫苗接种率增加 (5.7%),尽管这种差异在统计学上并不显著.
- 对知识结果观察到更高的异质性,对GS吸收结果观察到中等的异质性.
结论:
- 性别中立的策略似乎更有效地提高了学生对HPV疫苗接种的知识和意图.
- 虽然GN策略显示了更高采用率的趋势,但需要进一步的强有力的研究和更长的随访,以确认它们在实现疫苗接种率的统计学上显著增加方面绝对优于GS策略.
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