关于Streptococcus mutans的生长和发展的BerNPs的制造和评估
Tuyen Huu Nguyen1, Hong Thanh Pham2, Kieu Kim Thanh Nguyen3
1Laboratory of Biotechnology, Research Laboratories of Saigon Hi-Tech Park, Ho Chi Minh City, Vietnam.
Beilstein journal of nanotechnology
|March 5, 2025
概括
柏柏林纳米颗粒 (BerNPs) 通过破坏细胞膜并防止生物膜的形成,有效地抑制突变性菌株 (S. mutans). 这些纳米粒子为潜在应用提供了增强的生物可用性.
科学领域:
- 纳米技术纳米技术
- 微生物学 微生物学
- 材料科学 材料科学 材料科学
背景情况:
- 突变性链球菌 (S. mutans) 是导致牙的关键病原体.
- 柏柏林已知具有抗菌性质,但生物利用性有限.
- 纳米颗粒配方可以提高药物输送和疗效.
研究的目的:
- 为了准备和描述柏柏林纳米粒子 (BerNPs).
- 评估BerNPs对S. mutans的抗菌活性.
- 评估BerNP对S. mutans细胞结构和生物膜形成的影响.
主要方法:
- 湿方法使用球为BerNP制备.
- 使用FE-SEM,UV-vis,XRD和FTIR进行物理化学表征.
- 通过稀释 (MIC,MBC) 确定抗菌活性.
- FE-SEM用于分析细胞表面损伤和生物膜抑制.
主要成果:
- 合成的BerNP的平均颗粒大小为40-65nm.
- 在纳米粒子合成过程中没有观察到柏柏林的化学修饰.
- 针对S. mutans的BerNPs的MIC和MBC值分别为78.1和312.5微克/毫升.
- 贝尔NP诱导了显著的S. mutans细胞膜损伤,溶解,并抑制了生物膜的形成.
结论:
- 柏柏林纳米颗粒 (BerNPs) 已成功制备,具有增强的特性.
- 贝尔NP对结核菌突变菌具有强大的抗菌活性.
- 贝尔NP有效地抑制了S. mutans生物膜的形成,这表明了治疗潜力.
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