血液和呼吸道中树突细胞的水平和功能下降预测了COVID-19的严重程度
Björn Österberg1,2, Sara Falck-Jones1,2, Sindhu Vangeti1,2
1Division Immunology and Respiratory Medicine, Department of Medicine Solna Center for Molecular Medicine, Karolinska Institutet Stockholm Sweden.
Clinical & translational immunology
|March 5, 2025
概括
在COVID-19早期血液和呼吸道中低树突细胞 (DC) 水平预测了严重的疾病. 在严重病例中观察到单细胞变化,为呼吸道感染免疫病理学提供了洞察力.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 单细胞和树突细胞 (DCs) 对于免疫对感染的反应至关重要,影响先天性和适应性免疫力.
- 这些细胞在呼吸道感染,特别是SARS-CoV-2中的特定作用需要进一步阐明.
研究的目的:
- 研究COVID-19患者血液和呼吸道中的单细胞和DCs的纵向动态和功能.
- 为了将免疫细胞概况与COVID-19的严重程度和疾病进展相关联.
主要方法:
- 147名COVID-19患者的纵向采样,疾病严重程度各不相同.
- 流细胞计,蛋白质组学和体外托尔类受体 (TLR) 刺激试验.
- 在血液和呼吸道样本中分析免疫细胞分布,功能和细胞因子概况.
主要成果:
- 在COVID-19患者中观察到血液和呼吸道中DCs的水平降低,在症状发作后早期出现cDC2的频率较低,预测严重疾病.
- 严重的COVID-19与下呼吸道活化单细胞增加有关,而DC子集枯竭在严重病例中持续时间更长.
- 蛋白质组分析显示了单细胞/DC相关的细胞因子与疾病严重程度之间的关联;在康复期间血细胞频率正常化,除了血细胞DC.
结论:
- 严重的COVID-19的特点是呼吸道单细胞招募的独特模式,以及血液和呼吸道中DC水平的降低,这可能会导致疾病的严重程度.
- 疾病过程早期血液中DC水平较低,可以预测严重结果,为COVID-19免疫病理学提供了洞察力.
- 这些发现对治疗严重呼吸道感染有潜在的治疗意义.
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