皮层形态变化调解了淋巴系统功能与视严重程度之间的关系
Yilei Chen1, Jun Xu2, Yingnan Kong1
1Department of Radiology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
International journal of biomedical imaging
|March 5, 2025
概括
淋巴功能,通过在周脉空间 (DTI-ALPS) 进行扩散张力图像分析来评估,在适应性视 (AA) 中似乎受损. 这种损伤可能会通过改变大脑形态来加剧AA严重程度,这表明DTI-ALPS是潜在的生物标志物.
科学领域:
- 神经成像是一种神经成像.
- 眼科医生 眼科 眼科
- 神经学 神经学
背景情况:
- 适应性视障 (AA) 是一种常见的视力障碍.
- 淋巴系统功能障碍与各种神经疾病有关.
- 淋巴功能,大脑形态和AA严重程度之间的关系需要进一步调查.
研究的目的:
- 在AA患者中使用DTI-ALPS评估淋巴功能.
- 调查淋巴功能,皮质形态变化和AA严重程度之间的关联.
- 探索DTI-ALPS作为AA成像生物标志物的潜力.
主要方法:
- 预期招募50名AA患者和47名健康对照 (HC).
- 对所有参与者进行了扩散张力成像 (DTI) 和T1加权成像.
- 周围血管空间 (ALPS) 指数计算,大脑形态测量分析和相关性/调解分析与视调查量表 (ASS) 成绩的分析.
主要成果:
- 与HC相比,患有AA的患者在左上尾 (SOG.L) 的深度显著增加,并在几个左侧大脑区域 (STG.L,MOG.L,PoCG.L,PCUN.L) 的皮质厚度增加.
- 在AA患者中,ALPS指数明显低于HC患者.
- ALPS指数与SOG.L层深度和MOG.L皮质厚度有负相关性,这部分影响了ASS分数的影响.
结论:
- 受损的淋巴功能,以较低的ALPS指数来表示,与适应性视有关.
- 特定大脑区域的皮层形态变化可能会介导淋巴功能障碍对AA严重性的影响.
- 作为一个潜在的成像生物标志物,DTI-ALPS有望用于评估AA患者的淋巴功能.
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