患有心室外的儿童不应该服用阿司匹林吗? 更新: 0% 远端功能故障
Suhas Udayakumaran1, Shine Kumar2
1Division of Paediatric Neurosurgery, Department of Neurosurgery, Amrita Institute of Medical Sciences and Research Centre, Kochi, India.
Asian journal of neurosurgery
|March 5, 2025
概括
在患有心室内 (VA) 突变的儿科患者中使用阿司匹林显示出有前途的安全性和预防突变并发症的潜力. 需要进一步的长期研究来确认它对心脏问题的有效性.
科学领域:
- 儿科神经外科 儿科神经外科
- 心血管并发症 心血管并发症
- 医疗器械管理 医疗器械管理
背景情况:
- 腹腔门 (VA) 突变是对腹腔门 (VP) 突变的拯救生命的替代方案,但会带来心脏并发症的风险.
- 目前的指导方针缺乏针对VA分离患者的查,抗凝血和风险管理的具体方案.
- 远端血栓形成是一个重大问题,导致VA分流接受者的二次发病率.
研究的目的:
- 为了评估阿司匹林在改善VA分流的儿科患者的分流存活率方面的疗效.
- 评估阿司匹林在预防心脏并发症和与VA分流相关的远端血栓形成中的作用.
- 在这个患者群体中调查阿司匹林作为抗血小板剂的安全性.
主要方法:
- 2011年启动的前性观察性研究,正在进行患者随访.
- 包括标准包括获得医院伦理委员会批准和家庭同意.
- 所有儿科患者从术后第一天开始每天服用阿司匹林5mg/kg.
主要成果:
- 自2011年3月以来,已有13名患者接受了随访,随访时间从28个月到170个月不等.
- 到目前为止,在研究队列中没有观察到直接归因于VA分流的心脏并发症.
- 患者的随访正在进行中,并继续监测与分离相关的不良事件.
结论:
- 初步发现表明阿司匹林是一种安全且潜在有效的辅助疗法,用于儿童的VA分流.
- 这些令人鼓舞的安全性和疗效数据需要进一步调查长期结果.
- 需要更长的随访期来确定阿司匹林在预防慢性后果 (如肺高血压) 中的作用.
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