一个不寻常的令人担忧的乳酸化病例:大脑代谢交叉对话
Sivakumar R1, Sumit Roy Chowdhury1, Karma Ongmu Bhutia1
1Department of Neuroanaesthesiology and Critical Care, All India Institute of Medical Sciences, New Delhi, India.
Asian journal of neurosurgery
|March 5, 2025
概括
脑瘤手术会导致严重的乳酸化,即使生命体征稳定. 使用二碳酸 (NaHCO3) 及时治疗有助于使乳酸水平正常化,并确保患者康复.
科学领域:
- 神经外科 神经外科
- 麻醉学 麻醉学
- 关键护理医学 关键护理医学
背景情况:
- 轨道洞穴血管瘤是一种罕见的瘤,需要复杂的外科切除.
- 在长期的神经外科手术过程中,可能会出现代谢障碍,包括乳酸性酸症.
- 肥胖 (BMI 30.8 kg/m2),大瘤大小 (4×2×2 cm) 和手术压力都可能导致代谢障碍.
研究的目的:
- 在脑瘤手术期间报告显著的乳酸酸性化病例.
- 突出监测和管理神经外科中代谢障碍的重要性.
- 为了强调二碳酸在治疗手术期间乳酸的作用.
主要方法:
- 一名39岁的男性在全身麻醉下切除了左轨道洞穴血管瘤.
- 麻醉管理包括平衡麻醉和由脉冲压变化 (<12%) 指导的流体管理.
- 在整个手术过程中进行了动脉血液气体 (ABG) 分析,血液动力学监测和乳酸水平监测.
主要成果:
- 乳酸盐水平逐渐增加,达到10.6mmol/L与相关的酸血,尽管稳定的血液动力学.
- 通过保持平均动脉压 (70-80毫米平),毛细血管补充时间 (<3秒) 和中央静脉氧和 (72%) 排除了全身低 perfusion.
- 二碳酸盐 (NaHCO3) 的使用导致乳酸盐水平降低 (从8-9 mmol/L降至术后的6.4 mmol/L),促进了输出管和无故障恢复.
结论:
- 长时间的脑瘤手术,大瘤大小和更高的BMI都可能导致显著的乳酸性酸性疾病.
- 早期识别和干预,包括二碳酸盐的管理,对于在神经外科手术期间管理代谢性酸性疾病至关重要.
- 代谢障碍的有效管理确保了有利的患者结果和成功的康复.
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