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试验序列分析和分析 鼻内胺与鼻内阿片类药物用于儿科患者的止痛
Madhusudan Prasad Singh1, Alok Singh1, Ekta Krishna2
1Department of Pharmacology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.
Annals of neurosciences
|March 5, 2025
概括
鼻内胺 (KT) 在儿童疼痛缓解方面显示出与吸入性阿片类药物 (OPs) 相当的疗效,但具有明显更多的副作用,如头和不愉快的味道. 由于样本规模不足,需要进行进一步的研究.
科学领域:
- 麻醉学 麻醉学
- 儿科医学 儿科医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 胺 (KT) 已因其止痛和镇静性而闻名.
- 鼻内 (IN) 或吸入式KT已在儿科试验中用于疼痛和焦虑管理.
- 这一元分析比较了IN/吸入式KT与吸入式阿片类药物 (OPs).
研究的目的:
- 在儿科患者中评估IN/吸入式胺与吸入式阿片类药物的疗效和安全性.
- 为了比较疼痛反应,需要救援止痛药,镇静水平和不良事件.
- 确定IN/吸入式胺在儿科手术护理中的作用.
主要方法:
- 在主要数据库 (Cochrane Library,PubMed,ClinicalTrials.gov) 进行了系统的文献搜索,截至2024年2月.
- 包括随机临床试验,比较儿科患者的吸入式KT (单独或与标准护理) 与OP.
- 评估的关键结果包括疼痛反应,救援止痛药使用,镇静和不良事件 (AE),并进行了试验顺序分析 (TSA).
主要成果:
- 分析了7项涉及489名儿科患者的研究.
- 胺基组显示了与阿片类药物相比的疼痛反应和救援止痛需要.
- 然而,胺组经历的不良事件明显多,包括头和不愉快的味道,并实现了较高的轻度至中度镇静率.
结论:
- 氨酸的疗效与阿片类药物相当,但与更高的副作用发生率有关.
- 与胺相比,阿片类药物似乎提供了更好的耐受性.
- 结论是有限的,因为与最终发现所需的信息大小 (RIS) 相比,样本大小不足.
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