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Updated: May 24, 2025

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
07:09

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

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在ATO中的LncRNA MALAT1/Calpain-1轴诱导的hERG通道缺陷

Caichuan Yan1, Yuexin Li1, Xiaoxu Li1

  • 1Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, People's Republic of China.

Drug design, development and therapy
|March 5, 2025
PubMed
概括

三氧化物 (ATO) 通过增加MALAT1,激活calpain-1并减少hERG通道,导致心脏毒性. 坦辛IIA和fexofenadine可以抵消这种作用,为获得的长QT综合征 (acLQTS) 提供潜在的治疗方法.

关键词:
这是ATO的ATO.我们的LQTS马拉特语 马拉特语卡尔帕因-1 卡尔帕因-1希尔格 (HERG) 是一个

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