皮层厚度与自闭症谱系成年人感官运动症状之间的关系中的性别差异
David James1, Vicky T Lam1, Booil Jo1
1Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, California, USA.
Behavioural neurology
|March 5, 2025
概括
自闭症谱系障碍 (ASD) 显示了大脑结构和感官处理中的性别特异性差异. 左后中枢回形的厚度与ASD男性和典型的男性发育的感官问题相关.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 医疗成像医学成像
背景情况:
- 自闭症谱系障碍 (ASD) 的特点是皮层形态和感官处理的改变.
- 这些变化可能存在于典型发育 (TD) 个体的连续上.
- 皮层结构和感官处理之间的关系,以及其性别特异性的差异,尚未得到充分理解.
研究的目的:
- 调查自闭症和TD成年人中后中枢回环 (PCG) 皮层厚度和感官处理症状之间的联系.
- 为了确定这种关系是否在两性之间存在差异.
主要方法:
- 磁共振成像 (MRI) 用于测量23名自闭症和27名TD成年人的PCG皮质厚度.
- 修订的Ritvo自闭症阿斯伯格诊断尺度 (RAADS-R),专注于感官运动子尺度,评估了自闭症特征.
- 分析了PCG厚度和RAADS-R得分之间的相关性,按性别分层.
主要成果:
- 与TD组相比,自闭症组的左后中心 (PCG) 显著更厚.
- 这种差异在自闭症男性中尤为明显.
- 双边PCG厚度和RAADS-R感官运动子级别之间的正相关性在男性 (自闭症和TD) 中观察到,但在女性中没有.
结论:
- 这项研究揭示了PCG皮层厚度和自闭症个体的感官处理之间的关系的性别特异性差异,扩展到TD人群.
- 左PCG厚度可以作为一种潜在的性别特异性生物标志物,用于神经类型和自闭症人群的感觉运动功能.
- 这一发现可能有助于开发针对自闭症感官运动挑战的干预措施.
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