通过NIR-II成像对大脑进行动态病理生理洞察

通过NIR-II成像对大脑进行动态病理生理洞察

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Updated: May 24, 2025

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Si Chen^1,2, Hao Chen^2,3, Xinxin Li³

¹Department of Neurology, Xiangya Hospital, Central South University, Xiangya Road 88, Changsha, 410008, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|March 5, 2025

概括

新的有机纳米探测器使大脑血流和血脑屏障完整性的详细体内成像成为可能. 这一进展有助于对神经疾病和潜在干预措施的理解.

科学领域:

神经科学是一个神经科学.
生物医学工程生物医学工程
材料科学材料科学材料科学

背景情况:

大脑附带循环和血脑屏障 (BBB) 对大脑功能至关重要.
目前的诊断工具在评估动态神经血管单元功能方面存在局限性.
了解疾病中的附带输液和BBB变化是有限的.

研究的目的:

开发和评估用于体内脑血管成像的新型纳米探针.
评估这些纳米探针在可视化抵押流通和BBB完整性的潜力.
探索神经疾病模型中的应用.

主要方法:

从小分子染料和牛血清白蛋白中合成高晶半导体有机纳米探针 (4T-BSA).
在第二个近红外窗口 (NIR-II,1000-1700nm) 中的活体大脑血管成像.
在小鼠模型中评估成像透深度,信号与背景比率 (SBR) 和空间分辨率.

主要成果:

4T-BSA纳米探针在完整的小鼠大脑中显示出优异的成像透深度.
获得高SBR (6.0) 和50μm以下的大脑血管的空间分辨率.
在神经疾病模型中成功可视化了血管附带输液和白蛋白泄漏.
确定了与抵押流网络和BBB中断相关的病态活动.

结论:

4T-BSA纳米探针在NIR-II窗口中对活脑血管成像非常有效.
这些纳米探针为大脑附带循环和BBB完整性提供了宝贵的见解.
NIR-II成像对推进神经疾病的诊断和治疗具有前途.

关键词:

BBB 干扰 BBB 的干扰在NIR-II光中,光效应大脑附带循环的循环.结晶的有机纳米探测器实体脑部成像实体脑部成像

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