患有免疫媒介炎症疾病的患者心力衰竭风险:基于人口的研究
Sahil Koppikar1, Bindee Kuriya2, Jacob A Udell3
1S. Koppikar, MD, Lihi Eder, MD, PhD, Department of Medicine, University of Toronto, and Women's College Hospital, University of Toronto, Toronto.
The Journal of rheumatology
|March 5, 2025
概括
患有免疫媒介性炎症性疾病 (IMIDs) 的患者面临心力衰竭 (HF) 住院的风险更高. 这种增加的风险,在类风湿性关节炎中尤其显著,突显了IMID人群中心血管监测的重要性.
科学领域:
- 心血管医学 心血管医学
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 免疫媒介性炎症性疾病 (IMID) 与全身炎症有关.
- 心血管并发症,包括心力衰竭 (HF),在IMID患者中越来越多地被认可.
- 鉴于糖尿病 (DM),IMID患者与普通人群中HF的比较风险需要进一步阐明.
研究的目的:
- 评估免疫媒介性炎症性疾病 (IMIDs) 患者心力衰竭 (HF) 住院住院的风险.
- 将IMID患者的HF风险与一般人群进行比较,按糖尿病 (DM) 的存在或不存在分层.
主要方法:
- 在安大略省 (2011-2019) 进行的一项基于人口的队列研究包括患有类风湿性关节炎,轴性脊柱关节炎,牛皮关节炎和牛皮的患者.
- 首次住院治疗HF是主要的结果.
- 考克斯的比例危险模型被用来计算HF风险的危险比率 (HRs).
主要成果:
- 该研究分析了243,061名IMID患者,748,517名DM患者和8,278,934名对照人群.
- 与非IMID对照组相比,患有IMID的患者患高风险肺炎住院的风险更高 (HR 1.34).
- 风险在类风湿性关节炎 (HR 1.61) 中最高,在牛皮 (HR 1.09) 中较低. 患有DM的患者的风险明显更高 (HR 2.19).
结论:
- 患有免疫媒介炎症疾病的个体心力衰竭住院的风险较高.
- 心血管风险评估和管理对于IMID患者至关重要,特别是那些患有DM等并发症的患者.
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