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Updated: May 24, 2025

RNA-based Reprogramming of Human Primary Fibroblasts into Induced Pluripotent Stem Cells
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通过减少合成circRNA中的污染物来缓解细胞功能障碍,以实现高效的基于mRNA的细胞重编程.

Ziwei Zhang1, Weiyu Li1,2, Xiangyu Ren1,3

  • 1CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Chinese Academy of Sciences, Haidian District, Beijing, 100190, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|March 5, 2025
PubMed
概括

合成的循环RNA (circRNA) 杂质会触发免疫反应. 一种新的净化方法可以去除这些污染物,从而提高 circRNA 疗效,用于再生医学和癌症免疫疗法应用.

关键词:
细胞重新编程的重编程圆形的RNARNA是一个圆形的RNA.这就是 iPSC 的意义.mRNA疗法是一种mRNA疗法.净化策略的净化策略.

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