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Updated: Jun 14, 2025

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18 F-FDG PET/CT 在68 Ga-FAPI PET/CT 之前确定了直肠恶性病

Hui Wang¹, Minggang Su

¹Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, China.

Clinical nuclear medicine

|March 5, 2025

概括

氧葡萄糖 (18F-FDG) PET/CT在食道癌患者中比-68 (68Ga) 纤维细胞激活蛋白抑制剂 (FAPI) PET/CT更早发现直肠癌. 这突出了18F-FDG.

科学领域:

在瘤学瘤学.
核医学就是核医学.
放射性药物放射性药物放射性药物

背景情况:

消化管癌的管理需要准确的分期和监测.
双追踪器正子辐射断层扫描/计算机断层扫描 (PET/CT) 结合了不同的放射追踪器,用于全面的成像.
18F-FDG PET/CT是用于癌症成像的标准工具,而68Ga-FAPI PET/CT则针对与瘤相关的纤维细胞.

研究的目的:

报告食道癌症监测的情况,使用双标志物PET/CT.
为了比较18F-FDG和68Ga-FAPI PET/CT在治疗期间检测直肠恶性瘤的诊断效用.

主要方法:

一名69岁的患有食道癌症的男性接受了连续的双追踪器PET/CT扫描 (18F-FDG和68Ga-FAPI).
图像检测是在基线,临时治疗期间和监测期间进行的.
在手术后获得了直肠腺癌的组织病理学确认.

主要成果:

基线扫描显示没有直肠异常.
临时18F-FDG PET/CT显示了焦点直肠吸收,而68Ga-FAPI PET/CT则是负的.
监测扫描检测到异常活动在同一直肠区域与两个标志物,后来证实为腺癌.

结论:

在这种情况下,18F-FDG PET/CT 证明了能够比68Ga-FAPI PET/CT 早检测直肠恶性瘤的能力.
双标志物PET/CT可以在癌症监测中提供补充信息.
需要进一步的研究来阐明68Ga-FAPI在检测次要直肠恶性瘤中的确切作用.

关键词:

在18F-FDG中.68Ga-FAPIAPI 的使用情况.聚乙烯/聚乙烯/聚乙烯这是直肠腺癌 (rectal adenocarcinoma).

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