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在中国北部,高毒性百日咳 Bordetella与宏类耐药性急剧增加

Yahong Hu¹, Lin Zhou², Qianqian Du¹

¹Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics, Laboratory of Infection and Microbiology, Beijing PaediatricPediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, People's Republic of China.

Emerging microbes & infections

|March 5, 2025

概括

该研究显示,在中国北部,高毒性和抗红素的波尔代特菌百日咳菌株 (ptxP3-ERBP) 显著增加. 这种克隆传播与最近的百日咳复发有关,特别是在儿童中,这突显了需要进行强剂疫苗接种的必要性.

科学领域:

微生物学微生物学
遗传学遗传学是一个
流行病学流行病学

背景情况:

百日咳是由百日咳 Bordetella引起的,在全球范围内仍然是一个重大的公共卫生问题.
了解B. pertussis的遗传进化和抗菌素耐药性模式对于有效的疾病控制至关重要.

研究的目的:

调查2019年至2023年中国北部B. pertussis抗原基因型和抗菌耐药性的演变.
确定导致该地区近期百日咳复发的关键因素.

主要方法:

用PCR,测序,E测试和Kirby-Bauer盘扩散分析442个B.百日咳分离物.
七个抗原基因 (ptxA,ptxC,ptxP,prn,fim2,fim3,tcfA) 的基因定型.
选择的分离物的MLVA类型和全基因组测序.

主要成果:

高毒性ptxP3等位基因的急剧增加,从13.5% (2019-2021) 增加到93.0% (2022-2023).
在ptxP3分离物中,红色素耐药性 (ERBP) 的同时增加,从42.9%上升到100%.
3-14岁儿童咳病例增加,从2019年的13.5%上升到2023年的45.6%.

结论:

ptxP3-ERBP血统的克隆传播是中国百日咳复发的主要驱动因素.
调查结果强调需要加强监测和增强疫苗接种策略,特别是对于学龄儿童.

关键词:

百日咳 Bordetella 百日咳是一种疾病.中国中国中国中国.抗红素耐药性抗红素耐药性 MT28 一个人的生活.在Ptxp3中使用Ptxp3

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