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相关概念视频

Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

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Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
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Bone Structure01:55

Bone Structure

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Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
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Gene Conversion02:08

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Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
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Changes in the Appendicular Skeleton with Age01:09

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The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
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Bone Formation by Intramembranous Ossification01:29

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Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
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创造多样性的骨编辑转换

Fu-Peng Wu1, Jasper L Tyler1, Frank Glorius1

  • 1Organisch-Chemisches Institut, University of Münster, 48149 Münster, Germany.

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此摘要是机器生成的。

研究人员开发了新的骨编辑方法,以快速实现分子多样化. 这些转变允许同时进行骨修饰和功能组安装,加速结构-活动关系研究.

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科学领域:

  • 有机合成 有机合成
  • 药用化学 医学化学
  • 光催化作用的光催化

背景情况:

  • 骨架编辑使分子的后期修改成为可能,这对于探索化合物周围的化学空间至关重要.
  • 传统的骨编辑通常只产生一个产品,限制了结构-活性关系 (SAR) 研究所必需的多样化.
  • 开发允许快速多样化的骨编辑策略是加速药物发现的关键.

研究的目的:

  • 开发新的骨编辑转换,使同时进行骨修改和功能组合并成为可能.
  • 创建用于快速多样化分子支架的方法,从而加快SAR调查.
  • 探索用于骨架编辑和多样性生成的光催化方法.

主要方法:

  • 开发一种基于α-二二基的碳基等效试剂,用于光氧催化电离体的环膨胀.
  • 设计一个原子碳等价的试剂,用于Ciamician-Dennstedt型的极环扩张.
  • 光催化德梅奥反应用于循环环扩张和硫的 dearomative 环扩张.
  • 通过皮里丁环开放,油精和环关闭来发展原子转化为碳原子的发展.

主要成果:

  • 通过插入十多个功能化碳原子,促进了印尼体的环扩张.
  • 通过同时安装可实现功能化的氧胺手柄,实现了轻度和选择性的内环扩张.
  • 通过小环插入证明了循环和的光催化环扩张,允许多个产品访问.
  • 通过霍纳-瓦兹沃斯-埃蒙斯油精化,成功地将化转化为环,从而实现了通过霍纳-瓦兹沃斯-埃蒙斯油精化方法安装多种功能组.

结论:

  • 开发了新的骨编辑策略,允许同时进行骨修改和多样性生成.
  • 这些方法可以快速探索化学空间,并可以显著加快SAR调查.
  • 开发的转换提供了多功能工具,可以通过后期功能化访问各种分子架构.