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塞沃弗兰和普罗波对体外和小鼠模型中的血管透性的明显影响

Ru Li1, Yujie Huang2, Kevin Lin1

  • 1Department of Anesthesiology, Stony Brook University, Renaissance School of Medicine, Stony Brook, New York.

Anesthesiology
|March 5, 2025
PubMed
概括

吸入麻醉剂塞沃兰通过激活缺氧诱导因子1α (HIF-1α) 和血管内皮生长因子 (VEGF) 来增加血管通透性. 在这项研究中,普罗波没有影响内皮透气性.

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Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
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