心肌工作和类风湿性关节炎患者的疾病活动之间的相关性 保存左心室喷射分数:基于非侵入性压力-应变循环的回顾性研究:非侵入性压力-应变循环:
Xiaolong Yu1, Jing Xi1, Jiabiao Wu2
1Department of Ultrasonics, Wujin Hospital Affiliated with Jiangsu University, Changzhou, Jiangsu, China.
Clinical rheumatology
|March 5, 2025
概括
类风湿性关节炎 (RA) 疾病活动会损害心肌功能,特别是在疾病活性较高的患者中. 左心室压力-应变循环 (LV-PSL) 技术有效地检测到这些心脏功能变化在RA患者.
科学领域:
- 心脏病学 心脏病学
- 类风湿病学 类风湿病学
- 医疗技术 医疗技术 医学技术
背景情况:
- 在类风湿性关节炎 (RA) 患者中,亚临床心脏损伤很常见.
- 在自身免疫性疾病中,早期发现和治疗心脏损伤至关重要.
- 左心室压力-应变循环 (LV-PSL) 技术提供了一种非侵入性方法来评估心脏功能.
研究的目的:
- 评估使用LV-PSL在RA患者的左心室 (LV) 功能变化,保留LV喷射分数 (LVEF) 使用LV-PSL.
- 探索心肌工作 (MW) 和RA疾病活动之间的相关性.
主要方法:
- 根据DAS28得分,62名具有LVEF保存的RA患者被分为低,中和高疾病活性组.
- 包括一个由29名健康个体组成的对照组.
- LV-PSL评估了LV的全球纵向应变 (GLS) 和MW参数 (GCW,GWW,GWI,GWE);分析了与DAS28的相关性.
主要成果:
- 与对照组相比,具有高疾病活性的RA患者的GWI,GCW,GWE和GLS显著降低.
- 心肌工作参数 (GWI,GCW,GWE) 与LVEF和绝对GLS正相关.
- 全球浪费工作 (GWW) 与LVEF负相关.
结论:
- 风湿性关节炎疾病的活性与心肌功能受损密切相关.
- LV-PSL技术有效监测RA患者的心肌功能异常.
- 减少的心肌工作参数与RA疾病活性增加相关,为临床管理提供了见解.
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