具有不同外组成的相位移液滴的光学和声学表征
Sugandha Chaudhary1, Anuj Kaushik1, Bachir A Abeid2
1Department of Radiology, University of Michigan, Ann Arbor, Michigan 48109-5667, United States.
Langmuir : the ACS journal of surfaces and colloids
|March 5, 2025
概括
perfluorocarbon 滴滴的外成分对它们的声滴蒸发 (ADV) 值和有效载荷释放的影响最小. 然而,与蛋白质外相比,脂质外在ADV后表现出更高的稳定性和更慢的降解.
科学领域:
- 生物医学工程 生物医学工程
- 声学物理 声学物理
- 材料科学 材料科学 材料科学
背景情况:
- 稳定,相位转移的高碳水滴对超声波诊断和治疗有希望.
- 与传统的微气泡相比,对外构成对声滴蒸发 (ADV) 滴滴的影响不太了解.
研究的目的:
- 研究脂质,蛋白质和聚合物外组成如何影响 perfluorohexane 滴滴的稳定性,ADV 动态,增长,有效载荷释放和声学反应.
- 在超声波下,在模仿组织的水凝中比较不同外组合的行为.
主要方法:
- 使用微流体平台制造了带有脂质,蛋白质或聚合物外的微米大小的载荷滴.
- 在基于纤维素的水凝中进行了光学 (超高速,时间缩短的共聚焦显微镜) 和声学表征.
- 光标记器被用来跟踪外完整性和有效载荷释放后音响在2.5和9.6MHz.
主要成果:
- 与蛋白质和聚合物涂层液滴相比,脂涂层液滴的最大膨胀比率高达20%较低.
- 有效载荷释放速度很快 (数量级比泡增长快) 并显示对外类型的依赖程度很小.
- 脂质比蛋白质 (完全减少) 保持光时间更长 (40%在120秒),表明更好的稳定性. 在所有贝类型中,ADV和惯性化值是相似的.
结论:
- 的组成对 perfluorohexane 滴滴的声滴蒸发 (ADV) 和惯性空洞化值有有限的影响.
- 虽然外的组成影响着滴滴的膨胀和长期稳定性,但它对快速有效载荷释放动力学的影响很小.
- 与蛋白质外相比,脂质外在ADV后具有更高的稳定性,这可能与特定的超声波应用有关.
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