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Updated: May 24, 2025

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发现和优化新型的Apo-IDO1抑制剂的药基结构简化策略通过药基结构简化策略

Lifang Cen1, Yunze Wu1, Mingchao He2

  • 1Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, P. R. China.

Journal of medicinal chemistry
|March 5, 2025
PubMed
概括

新的Apo-IDO1抑制剂为癌症免疫治疗提供了一个有希望的策略. 开发的化合物XW-032在体外和体内表现出强烈的抗瘤活性,这表明持续的目标参与提高了疗效.

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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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