免疫检查点抑制剂诱导的肺炎患者的长期结果
Andrea Davis1, Douglas B Johnson2, Julie A Bastarache3
1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA andrea.davis.1@vumc.org.
BMJ open respiratory research
|March 5, 2025
概括
免疫检查点抑制剂 (ICI) 肺炎往往导致住院和不良结果,包括死亡. 由于ICI肺炎而入院与较差的长期存活率有关,而不管先前存在的肺部疾病.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 增强抗癌免疫力,但可能导致与免疫相关的不良事件.
- 肺炎是一种与ICI相关的严重肺毒性,对患者长期结局的数据有限.
研究的目的:
- 调查ICI治疗期间发生肺炎的患者的短期和长期结果.
- 确定与ICI相关肺炎的不良结果相关的因素.
主要方法:
- 对超过250万患者的电子健康记录进行了回顾性分析.
- 根据症状,CT成像和ICD-10代码确定了78名可能患有肺炎的患者.
- 收集了有关人口统计,ICI疗法,住院和生存率的数据.
主要成果:
- 78名患者中有52人因肺炎需要住院治疗,其中25人短期表现不佳 (包括9人死亡).
- 37%的患者在8.3个月的中位数随访期间还活着.
- 肺炎入院与死亡率增加和进一步治疗或长期无病生存的可能性降低有关.
结论:
- 与ICI相关的肺炎经常需要住院治疗,并与显著的发病率和死亡率有关.
- 患有ICI肺炎的住院患者面临更糟糕的结果.
- 在患有先前存在的肺部并发症的患者中,没有观察到结局的差异.
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