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Updated: May 5, 2026

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用DNA编码的图书馆屏幕识别了新一系列呼吸道同胞病毒聚合酶抑制剂

Sean M Carney1, Sandrine Grosse2, Yanting Yin1

  • 1Janssen Research & Development, LLC, Johnson & Johnson Company, Spring House, Pennsylvania 19002, United States.

Journal of medicinal chemistry
|March 5, 2025
PubMed
概括

研究人员发现了新的强效抑制剂,向呼吸道同胞性病毒 (RSV) 聚合酶. 这些发现为开发针对RSV感染的新型抗病毒疗法提供了有希望的途径.

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Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
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